Dr.Nod: Discovery of Regulatory NOn-coding Drivers
A paper titled, "Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements" by Tomkova et al. 2023 was recently published in Nucleic Acid Research.
In this paper, the authors propose the novel framework Dr.Nod for detection of non-coding regulatory candidate driver mutations associated with dysregulation of genes in cancer. The research showed that non-coding driver mutations contribute to cancer by altering transcription factor binding sites that lead to upregulation of oncogenes and downregulation of tumor suppressor genes.
Tomkova M, Tomek J, Chow J, McPherson JD, Segal DJ, Hormozdiari F. 2023. Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements. Nucleic Acids Research, gkac1251. DOI: 10.1093/nar/gkac1251.