Dr.Nod: Discovery of Regulatory NOn-coding Drivers

A paper titled, "Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements" by Tomkova et al. 2023 was recently published in Nucleic Acid Research.

In this paper, the authors propose the novel framework Dr.Nod for detection of non-coding regulatory candidate driver mutations associated with dysregulation of genes in cancer. The research showed that non-coding driver mutations contribute to cancer by altering transcription factor binding sites that lead to upregulation of oncogenes and downregulation of tumor suppressor genes.