Recent Publications: February 2020
Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion
This recent publication by Dodge et al. (2020) in Autism Research describes Ube3a, the gene responsible for Angelman syndrome. To facilitate future study on Angelman syndrome, the authors have generated a novel rat model with the loss of Ube3a expression. Read more.
Fecal Metatranscriptomics and Glycomics Suggest that Bovine Milk Oligosaccharides are fully Utilized by Healthy Adults
In the Journal of Nutritional Biochemistry, Westreich et al. (2020) investigate the differences in the digestion of oligosaccharides derived from bovine milk and human milk. Bovine milk oligosaccharides were found to be fully digested in the human gastrointestinal tract. Read more.
High Rate of Extrapair Paternity in a Human Population Demonstrates Diversity in Human Reproductive Strategies
Scelza et al. (2020) test the evolutionary theory that extrapair paternity is relatively low. The authors find that the rate of extrapair paternity in a community of Himba pastoralists is 48%, with 70% of couples having at least one extrapair paternity child. Therefore, there is a range of variation in extrapair paternity across human populations. Read more.
A Missense Variant Affecting the C-Terminal Tail of UNC93B1 in Dogs with Exfoliative Cutaneous Lupus Erythematosus (ECLE)
This publication by Leeb et al. (2020) in Genes characterizes the causative variant of exfoliative cutaneous lupus erythematosus to chromosome 18, with the variant predicted to affect the C-terminal tail of UNC93B1. These dog-specific findings provide insight into human lupus erythematosus. Read more.
Comprehensive Circulator Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids
This recent publication in MDPI Metabolites (Germain et al. 2020) investigates the metabolomic characteristics of patients who suffer from myalgic encephalomyelitis/chronic fatigue syndrome. Read more.
Whole Genome Sequence Analysis Reveals the Broad Distribution of the RtxA type 1 Secretion System and four Novel Putative type 1 Secretion Systems Throughout the Legionella genus
In PLOS One, Brown et al. (2020) describe their discovery of a membrane fusion protein in a novel Legionella taurinensis strain. Read more.
Cotton Leaf Curl Multan Virus βC1 Protein Induces Autophagy by Disrupting the Interaction of Autophagy-related Protein 3 with Glyceraldeyde-3-phosphate Dehydrogenases
In this paper, the authors show that CLCuMuB βC1 activates autophagy by disrupting GAPCs-ATG3 interactions, providing insight into the mechanism by which viruses induce autophagy. Read more.
Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9
Dong et al. (2020) report on their use of CRISPR-Cas9 to achieve the targeted insert of a carotenoid biosynthesis cassette into rice, indicating that gene insertion of marker-free DNA in rice is possible. Read more.
Limited Number of Cases May Yield Generalizable Models, a Proof of Concept in Deep Learning for Colon Histology
In the Journal of Pathology Informatics, Holland et al. (2020) show that increasing the number of images in a training dataset does not always improve model accuracy. Read more.
Metagenome-assembled Genomes Provide New Insight into the Microbial Diversity of Two Thermal Pools in Kamchatka, Russia
This recent publication by Wilkins et al. (2020) in Scientific Reports, investigated the diversity within two hot springs within an active volcanic ecosystem on the Kamchatka Peninsula in Russia. The authors obtained 36 draft metagenome-assembled genomes from environmental DNA. Read more.
Please email genomecenterweb@ucdavis.edu if you have a publication that you would like included next month.