About Us

Established in 2003 the UC Davis Genome Center uses state-of-art-technologies to understand how the heritable genetic information of diverse organisms function in health and disease

Genomic studies are revolutionizing biology and the Genone Center is at the forefront of this revolution. We are home to an internationally renowned faculty whose research interests exploit cutting-edge technologies for generating and interpreting vast amounts of data at all levels, from genes to entire organisms and populations. Innovative experimental science interfaces with the latest in computer capabilities to generate advances in basic biology, agriculture, human and veterinary medicine, biomedical engineering and computer science.

The diversity of organisms studied at UC Davis is one of its biggest strengths. The Genome Center bolsters this strength by providing genomics technologies on an at-cost, as-needed basis to all Davis faculty through its service cores that specialize in DNA analysis, gene expression, proteomics, metabolomics, and bioinformatics. Through collaborations and access to the enabling technology cores, the Genome Center serves the basic and translational research needs of all UC Davis faculty whose studies encompass human and animal diseases, food and biofuel crops, biodiversity and environmental health, as well as hitherto little-studied or unknown organisms.

These discoveries provide the raw information that is being translated into advances in medicine, agriculture and the sustainability of our global society.

Find out more about the Genome Center

Upcoming Talks and Events

Events on February 20, 2015
Seminar — Dr Hao Chen — Allele-specific copy number profiling by next-generation DNA sequencing
Starts: 9:00 am
Ends: February 20, 2015 - 10:00 am
Location: GBSF Room 4202
Description: Part of the Genome Center Structural and Functional Genomics Seminar Series


Abstract

The progression and clonal development of tumors often involve amplifications and deletions of genomic DNA. Estimation of allele-specific copy number, which quantifies the number of copies of each allele at each variant loci rather than the total number of chromosome copies, is an important step in giving a more complete portrait of tumor genomes and the inference of their clonal history. We propose a novel method, falcon, for finding somatic allele-specific copy number changes by next generation sequencing of tumors with matched normal. Falcon is based on a change-point model on a bivariate mixed Binomial process, which explicitly models the copy numbers of the two chromosome haplotypes and corrects for local allele-specific coverage biases. By using the Binomial distribution rather than a normal approximation, falcon more effectively pools evidence from sites with low coverage. We applied this method in the analysis of a pre-malignant colon tumor sample and late-stage colorectal adenocarcinoma from the same individual. The allele-specific copy number estimates obtained by falcon allow us to draw detailed conclusions regarding the clonal history of the individual’s colon cancer.
Events on March 4, 2015
Dr Janine LaSalle — Seminar — Mapping the Placental Methylome at the Interface of Genetics and Environment in Autism Risk
Starts: 12:00 pm
Ends: March 4, 2015 - 1:00 pm
Location: Center for Health and Technology room 1341, 4610 X St Sacramento
Description: Part of the Human Genomic Seminar Series

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